The Ptch methylase installs an m3U modification on 28S rRNA for efficient protein synthesis in flies and men
Jie Chen, Yaofu Bai, Yuantai Huang, Min Cui, Yiqing Wang, Zhenqi Gu, Xiaolong Wu, Yubin Li, Yikang S. Rong
The paper identifies m3U modification on 28S rRNA in flies and humans, showing Ptch enzymes are essential for this modification and its role in ribosomal function.
Science Advances · Dec 13, 2024Peer-reviewedGenetics