Yikang S. Rong

The U6 snRNA capping enzyme Amus/MePCE is required for the stability of U6atac and the processing of introns with features of both major and minor classes

The paper identifies a role for Amus/MePCE in stabilizing U6atac and shows that some minor introns require both major and minor splicing pathways for processing.

Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila

This study shows that Mettl5 regulates sleep in Drosophila by affecting PERIOD protein levels through translational control and proteasome function.

Angel Wing: a class of alternative splicing regulators in animals

This study identifies Angel wing (Anw) as an alternative splicing regulator, showing its role in muscle function and disease relevance in humans.

The Ptch methylase installs an m3U modification on 28S rRNA for efficient protein synthesis in flies and men

The paper identifies m3U modification on 28S rRNA in flies and humans, showing Ptch enzymes are essential for this modification and its role in ribosomal function.

Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs

The paper shows Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for U6 snRNA capping and stabilization, with distinct roles in 7SK snRNA stability.

The nanoCUT&RUN technique visualizes telomeric chromatin in Drosophila

The paper introduces nanoCUT&RUN, a modified CUT&RUN technique for mapping chromatin protein binding sites in Drosophila, showing its effectiveness for TRL, HipHop, and HOAP proteins.

Kinetic principles underlying pioneer function of GAGA transcription factor in live cells

The paper studies the kinetic behavior of the GAGA transcription factor in live Drosophila cells, showing it stably binds chromatin for over 2 minutes, independent of chromatin remodelers.

JiangShi: a widely distributed Mucin-like protein essential for Drosophila development

This paper identifies JiangShi (JS), a Mucin-like protein in Drosophila, and shows its essential role in development through loss and over-production studies.

Compensatory replacement of the BigH1 variant histone by canonical H1 supports normal embryonic development in Drosophila

The paper shows that maternal H1 can compensate for the absence of BigH1 in Drosophila embryos, supporting normal development.