Myeloid HIF-1α Sustains Hypoxic Fibrotic Fronts and Drives Pulmonary Fibrosis
Yuanyi Wei, Christopher M. Bailey, Peng Zhang, Jose Herazo-Maya, Τheodoros Karampitsakos, Joseph D. Pescrille, Felisa Diaz‐Mendez, Daniel Lee, Andriy O. Samokhin, Yan Liu, Wonder P. Drake, Yin Wang
This study identifies myeloid HIF-1 as a driver of pulmonary fibrosis by sustaining hypoxic fronts and promoting fibroblast activation and matrix remodeling.
bioRxiv · Mar 11, 2026 · PreprintPathology