The L1 Cell Adhesion Molecule Constrains Dendritic Spine Density through Ankyrin Binding in Pyramidal Neurons of the Mouse Cerebral Cortex
Kelsey E. Murphy, Sarah D. Wade, Justin E. Sperringer, Vishwa Mohan, Bryce W. Duncan, Yubin Pak, David Lutz, Melitta Schachner, Patricia F. Maness
This study identifies L1 cell adhesion molecule's role in regulating dendritic spine density via Ankyrin binding in mouse pyramidal neurons, showing increased spine density in L1 mutants and impaired spine pruning in response to Semaphorins.
bioRxiv · May 16, 2022 · PreprintNeuroscience