Sarah D. Wade

The paper develops a genetically encoded reporter to detect IFN responses in brain and peripheral tissues, revealing coordinated responses in neurons and non-neuronal cells across various conditions.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

This study identifies Nptx2 as a regulator of complement activity in the brain, showing its role in preventing microglial synapse elimination in health and disease.

This study identifies L1 cell adhesion molecule's role in regulating dendritic spine density via Ankyrin binding in mouse pyramidal neurons, showing increased spine density in L1 mutants and impaired spine pruning in response to Semaphorins.

This study identifies Sema3F's role in dendritic spine pruning through Rho-GTPase signaling pathways in cortical neurons.