Author

Yujia Zhang

Rice University

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Biology Disciplines

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Biophysics· 2

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Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:diffusion model· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Oleg A. IgoshiniD· 2 shared Brenda Zarazúa‐Osorio· 1 shared Cristina S.D. PalmaiD· 1 shared Masaya FujitaiD· 1 shared Zhuo CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

Oleg A. IgoshinORCID

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2 papers

Recent·Most cited

Integrating cell-state and enhancer constraints discriminates models of PU.1 regulation during hematopoietic differentiation

Yujia Zhang, Oleg A. Igoshin

The paper tests a dynamical model of PU.1 regulation during hematopoietic differentiation and finds that additional regulatory inputs beyond autoregulation and C/EBP feedback are required to explain observed data.

bioRxiv · Oct 4, 2026 · PreprintBiophysics

Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving Bacillus subtilis

Yujia Zhang, Cristina S.D. Palma, Zhuo Chen, Brenda Zarazúa‐Osorio, Masaya Fujita, Oleg A. Igoshin

The paper develops a biophysical model to elucidate how Spo0A[~]P binding to its regulatory boxes affects spo0A transcription in Bacillus subtilis, revealing repressive effects and the role of RNAP holoenzyme levels in expression increase.

mSystems · Apr 29, 2025Peer-reviewedBiophysics