Author

Zhuo Chen

Rice UniversityORCID 0000-0002-4001-0452Unclaimed ORCID profile · follow to get notified of new preprints

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Zhuo Chen2 papers · Sichuan University

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Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

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Brenda Zarazúa‐Osorio· 1 shared Cristina S.D. PalmaiD· 1 shared Masaya FujitaiD· 1 shared Oleg A. IgoshiniD· 1 shared Yujia Zhang· 1 shared

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Brenda Zarazúa‐Osorio

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BiophysicsmSystemsPeer-reviewedApr 29, 2025

Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving Bacillus subtilis

Yujia Zhang, Cristina S.D. Palma, Zhuo Chen…·Oleg A. Igoshin

The paper develops a biophysical model to elucidate how Spo0A[~]P binding to its regulatory boxes affects spo0A transcription in Bacillus subtilis, revealing repressive effects and the role of RNAP holoenzyme levels in expression increase.

5 citations

bacteria (other)biophysical modeling

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