Masaya Fujita

The paper develops a biophysical model to elucidate how Spo0A[~]P binding to its regulatory boxes affects spo0A transcription in Bacillus subtilis, revealing repressive effects and the role of RNAP holoenzyme levels in expression increase.

This study uses mathematical modeling and experiments to show that growth rate fluctuations and bistability in a regulatory network explain single-cell heterogeneity in biofilm matrix production and sporulation in Bacillus subtilis.