Oleg A. Igoshin

The paper tests a dynamical model of PU.1 regulation during hematopoietic differentiation and finds that additional regulatory inputs beyond autoregulation and C/EBP feedback are required to explain observed data.

This paper develops a cell-based therapy that enables sustained, dose-tunable delivery of monoclonal antibodies through a single administration, demonstrating long-term efficacy and safety in preclinical models.

This paper develops a mathematical framework to analyze molecular glues, showing that strong ternary complex binding affinity is key for performance, with degrader performance limited by catalytic efficiency and target half-life.

This study examines how different inhibitors affect enzyme specificity, finding that noncompetitive and mixed inhibitors can alter specificity, while competitive and uncompetitive inhibitors do not.

This paper uses deep learning to quantify dynamic self-organization in Myxococcus xanthus by encoding microscopy images into interpretable features that predict developmental phenotypes.

The paper models the σE biochemical network to show how transcriptional and post-translational regulation interact to control σE activity under stress, revealing context-dependent feedback mechanisms.

This study challenges the traffic jam model of Myxococcus xanthus aggregation by showing streams are not essential for aggregate formation but may accelerate it, with a genetic component to streaming.

This study identifies a dual regulatory mechanism and substrate limitations that balance quinone synthesis benefits and toxicity in Lactococcus lactis.

This study develops a theoretical model to explain sequence-dependent transcriptional error rates, revealing how downstream nucleotides influence RNA polymerase II fidelity.

This paper shows that Spo0A~P pulsing frequency controls biofilm matrix deactivation in B. subtilis, independent of growth rate effects on gene dosage and protein dilution.

The paper develops a kinetic model of CRISPR-Cas9 substrate selection and cleavage, showing specificity improvements arise from kinetic changes, not binding affinity.

The paper develops a biophysical model to elucidate how Spo0A[~]P binding to its regulatory boxes affects spo0A transcription in Bacillus subtilis, revealing repressive effects and the role of RNAP holoenzyme levels in expression increase.

This study evaluates the pharmacokinetics of a human mAb in different mouse strains to identify suitable models for preclinical testing.

The paper analyzes 1D aggregation models of bacterial populations with non-exponential reversal times, showing they improve aggregate formation and persistence.

This paper develops a mathematical model to explain IL-12 pharmacokinetic desensitization, showing that reduced bioavailability, not increased clearance, best explains clinical data.

The paper shows that proteins interact with the endoplasmic reticulum to accumulate near the nucleus without energy expenditure, following Chapmans law instead of Ficks law.

This study uses mathematical modeling and experiments to show that growth rate fluctuations and bistability in a regulatory network explain single-cell heterogeneity in biofilm matrix production and sporulation in Bacillus subtilis.

The paper shows that bacteriophage lambda uses viral replication to reliably count infecting genomes, leading to lysogenic or lytic decisions based on multiplicity of infection.

The paper demonstrates that mean and noise of gene expression can be independently controlled in E. coli by using two inducible promoters and shows how repressor noise affects promoter response.

The paper develops a deep-learning model to convert phase-contrast images into fluorescence-like images for better analysis of bacterial aggregation and rippling behaviors in Myxococcus xanthus.

The paper investigates stress-sensing mechanisms in Mycobacterium tuberculosis and M. smegmatis, showing hysteresis in pathogenic bacteria and revealing the role of DnaK in enabling fast and sustained responses.

This study uses mathematical modeling to investigate how positive and negative feedback loops in the PhoPQ two-component system influence its dynamical responses and steady-state behavior.

This paper describes a synthetic genetic circuit in E. coli that enables asymmetric cell division through plasmid partitioning, leading to differentiated daughter cells.

The paper investigates the role of C-signaling in posttranslational activation of FruA, a transcription factor necessary for spore commitment in Myxococcus xanthus during starvation.

The paper presents an agent-based model to simulate mechanical interactions in growing rod-shaped bacterial populations and demonstrates its application in microfluidic traps.