Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation
Anlan Yang, Shengjie Liu, Yuqi Zhang, Jia Chen, Yujing Fan, Fengxiang Wang, Yilong Zou, Shan Feng, Jianping Wu, Qi Hu
The paper reports cryo-EM structures of DHHC9-GCP16 and Erf2-Erf4 complexes, revealing that GCP16 stabilizes DHHC9 and that phospholipid binding and specific palmitoylation are essential for catalytic activity.
Nature Structural & Molecular Biology · Jan 5, 2024Peer-reviewedMolecular Biology