Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation
Anlan Yang, Shengjie Liu, Yuqi Zhang…·Qi Hu
The paper reports cryo-EM structures of DHHC9-GCP16 and Erf2-Erf4 complexes, revealing that GCP16 stabilizes DHHC9 and that phospholipid binding and specific palmitoylation are essential for catalytic activity.