IL-17A Mediates Cardiac Hypertrophy in Chronic Kidney Disease through the IL-23/Th17 Axis.
Fumihiko Ogata, Shinsuke Hanatani, Yuki Okuno, Masahiro Yamamoto, Kei Morikawa, Takumi Nagakura, Satoshi Araki, Eiichiro Yamamoto, Yuichiro Arima, Yasuhiro Izumiya, Kenichi Tsujita
This study shows that IL-17A promotes cardiac hypertrophy in CKD via the IL-23/Th17 axis, with IL-12p40 as a potential biomarker and therapeutic target.
bioRxiv · Sep 23, 2026 · PreprintPhysiology