Generalization but not strengthening of negative memories drives the development of depression-like behaviors
Xin Ran Cheng, Yubo Hu, Yan Zhao, Panwu Zhao, Xiaomeng Bai, Yi Chen, Deshan Kong, Shuyu Zheng, Yuena Zheng, Yumeng Wang, Yanni Zeng, Wei‐Jye Lin, Xiaojing Ye
The study distinguishes between memory strengthening and generalization, finding that memory generalization, not strengthening, drives depression-like behaviors through mPFC-BNST circuit mechanisms.
bioRxiv · Feb 10, 2025 · PreprintAnimal Behavior & Cognition