The HDAC2-selective inhibitor KTT-1 attenuates autoimmune arthritis by inhibiting osteoclast differentiation in mice
Yumi Ogihara, Wei Zhe, Yotaro Kodaira, Toshifumi Tojo, Yukihiro Itoh, Takayoshi Suzuki, Daisuke Takahashi, Koji Hase
The paper shows that KTT-1, a selective HDAC2 inhibitor, reduces arthritis symptoms in mice by inhibiting osteoclast differentiation without severe side effects.
bioRxiv · Oct 20, 2025 · PreprintImmunology