Koji Hase

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

The paper shows that infant acquisition of Stickland-metabolizing bacteria prevents Clostridium botulinum infection by competing for amino acids.

This study identifies LRP1 as the receptor for L-PTC/BOkra to enter the gut, showing HA binds to LRP1 via N-glycans and facilitates transcytosis.

This study shows that microbiome-host interactions in Drosophila create a trade-off between sleep quality and lifespan through specific bacterial metabolites and host responses.

The paper shows that KTT-1, a selective HDAC2 inhibitor, reduces arthritis symptoms in mice by inhibiting osteoclast differentiation without severe side effects.

This study shows dietary soy enhances T follicular helper cells and IgA in mice by promoting specific gut bacteria that drive mucosal immunity and protect against Salmonella.

This study shows that anti-amyloid beta therapy improves stroke recovery in the presence of cerebral amyloid beta accumulation by resolving myeloid immunity impairment.

This study identifies M-Sec as a regulator of CSF-1 receptor activation by promoting Fms aggregate formation through PIP2 binding.