Mechanosensitive FHL2 tunes endothelial function
Shailaja Seetharaman, John Michael Devany, Ha Ram Kim, Emma J. van Bodegraven, Theresa A. Chmiel, Tzu‐Pin Shentu, Wen-hung Chou, Yun Fang, Margaret L. Gardel
This study identifies FHL2 as a mechanosensitive protein that drives endothelial dysfunction under athero-prone flow conditions by modulating adherens junctions and Rho-ROCK signaling.
The EMBO Journal · May 26, 2026Peer-reviewedCell Biology