Tzu‐Pin Shentu

This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

This study identifies FHL2 as a mechanosensitive protein that drives endothelial dysfunction under athero-prone flow conditions by modulating adherens junctions and Rho-ROCK signaling.

This paper develops a modular nanoparticle platform for targeted mRNA delivery to inflamed endothelial cells, showing efficacy in treating ARDS and atherosclerosis by restoring disease-related gene pathways.

This study identifies a genetic variant at 1p32.2 that regulates endothelial responses to hemodynamics by modulating an enhancer region in vascular endothelium.