Construction of recombinant Bacillus subtilis spores surface-displaying PRRSV ORF1b, GP5, M, and N proteins in tandem and evaluation of their immunogenicity in mice
Yang Yang, Jianzhen Li, Pengfei Fang, Bin Chen, Yicen Tang, Xixi Dai, Lei Fei, Yunfei Xiao, Yanpeng Dong, Chunfeng Shi, Xueqin Ni, Bo Jing, Yoh Zen, Kangcheng Pan
This study constructs a recombinant Bacillus subtilis spore displaying PRRSV proteins and evaluates its immunogenicity in mice, showing enhanced mucosal and systemic immune responses.
bioRxiv · Jul 1, 2025 · PreprintImmunology