Proteolytic processing of Argonautes in multiphase condensates promotes transgenerational epigenetic inheritance
Boyuan Deng, Xufang Niu, Haiqian Ma, Lufan Shi, Changfeng Zhao, Wanlin Chen, Xinru Li, Yuntao Liang, Shuyu Hu, Ken Chen, Yonglin Liang, Yanhong Qiu, Haoxiang Jia, Gang Wan
The paper identifies a proteolytic mechanism in C. elegans that enables transgenerational epigenetic inheritance by processing Argonautes in germ granule subcompartments.
bioRxiv · Jan 2, 2026 · PreprintCell Biology