CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders
Kitty B. Murphy, Yuqian Ye, Maria Tsalenchuk, Alexi Nott, Sarah J. Marzi
CHAS deconvolves bulk H3K27ac profiles to infer cell type-specific signatures in neurological and psychiatric disorders, revealing distinct genetic and epigenetic contributions across cell types.
Cell Reports Methods · Apr 28, 2025Peer-reviewedGenomics