J. Timothy Greenamyre

This study identifies region-specific epigenomic and transcriptomic changes in a rotenone rat model of Parkinson's disease, highlighting immune and synaptic dysregulation in the substantia nigra and cortex.

This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.

This study shows that inhibiting LRRK2 kinase activity reduces ROS and protects against mitochondrial toxicity from environmental toxicants in both in vitro and in vivo models of Parkinson's disease.

The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.

The paper identifies VGLUT expression as a sex-dependent mediator of age-related dopamine neuron vulnerability in Parkinson's disease.

The paper shows that overexpressing TOM20 in rat midbrain neurons prevents α-synuclein-induced dopaminergic neurodegeneration by restoring mitochondrial protein import.

This study shows that disulfide bridge formation in CaMKII disrupts its interaction with calmodulin in Parkinson's disease, linking oxidative stress to impaired Ca2+/CaM signaling.