Author
University of PittsburghORCID 0000-0003-3719-3371Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Maria Tsalenchuk, Kyle Farmer, Sandra L. Castro…·Sarah J. Marzi
This study identifies region-specific epigenomic and transcriptomic changes in a rotenone rat model of Parkinson's disease, highlighting immune and synaptic dysregulation in the substantia nigra and cortex.
Matthew T. Keeney, Eric K. Hoffman, Julie Weir…·J. Timothy Greenamyre
This study identifies 15-lipoxygenase-mediated lipid peroxidation as a regulator of LRRK2 kinase activity, linking it to Parkinson's disease pathogenesis.
Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer…·Roberto Di Maio
The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.