ppGpp functions as an alarmone in metazoa
Doshun Ito, Hinata Kawamura, Akira Oikawa, Yuta Ihara, Toshio Shibata, Nobuhiro Nakamura, Tsunaki Asano, Shun-ichiro Kawabata, Takashi Suzuki, Shinji Masuda
This study detects ppGpp in Drosophila and human cells and shows it induces metabolic changes, cell death, and lethality in Drosophila, establishing its role as an alarmone in metazoans.
Communications Biology · Nov 13, 2020Peer-reviewedMolecular Biology