Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling
Yunxing Shi, Zongfeng Wu, Shaoru Liu, Dinglan Zuo, Yi Niu, Yuxiong Qiu, Liang Qiao, Wei A. He, Jiliang Qiu, Yunfei Yuan, Guocan Wang, Binkui Li
This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.
Nature Communications · Sep 10, 2024Peer-reviewedCancer Biology