An efficient artificial esterase with a dynamic conformation via conformational engineering
Yan Wang, Yi Cao, Yuanyuan Liu, Yuye Cao, Tiange Gao, Jiewen Deng, Tongtong Zhou, Haifang Wang, Aoneng Cao
This study creates an artificial esterase with enhanced catalytic efficiency by engineering dynamic active centers, achieving a kcat 5-fold higher than natural chymotrypsin.
bioRxiv · Jun 26, 2025 · PreprintBiochemistry