Both Determinants of Allosteric and Active Sites Responsible for Catalytic Activity of Delta 12 Fatty Acid Desaturase by Domain Swapping
Haisu Shi, Jinlong Tian, Chen Wu, Mo Li, Feiyu An, Rina Wu, Junhua Shao, Yan Zheng, Xue Gang Luo, Dongbing Tao, Xu Chen, Yuzhen Pi, Chunyan Zhao, Xiqing Yue, Junrui Wu
This study identifies key amino acid residues and domains in FADS12 that influence catalytic activity and inhibition through domain swapping between two fungal species.
bioRxiv · Oct 1, 2019 · PreprintMolecular Biology