Salmonella exploits metal-responsive UMPylation to enable intracellular biphasic growth and antibiotic tolerance
Weiwei Wang, H L Jia, Yongyu Wang, Qingjie Bai, Ruirui Liu, Ting Sun, Yingying Yue, X Wang, Yunzhuo Zhao, Xiaoyu Liu, Xilu Yuan, Rongxian Xie, Nannan Song, Yuzhen Wang, Zhongrui Ma, , Bingqing Li
This paper identifies a metal-responsive UMPylation mechanism in Salmonella that enables intracellular biphasic growth and antibiotic tolerance by modulating protein aggregation and translational arrest.
bioRxiv · Feb 10, 2026 · PreprintMicrobiology