This study identifies SseK1 as a bacterial effector that inhibits host SUMOylation by modifying UBC9, impairing immune responses and aiding Salmonella survival.

bioRxiv · Mar 8, 2026 · PreprintBiochemistry

Salmonella exploits metal-responsive UMPylation to enable intracellular biphasic growth and antibiotic tolerance

Weiwei Wang, H L Jia, Yongyu Wang, Qingjie Bai, Ruirui Liu, Ting Sun, Yingying Yue, X Wang, Yunzhuo Zhao, Xiaoyu Liu, Xilu Yuan, Rongxian Xie, Nannan Song, Yuzhen Wang, Zhongrui Ma, , Bingqing Li

This paper identifies a metal-responsive UMPylation mechanism in Salmonella that enables intracellular biphasic growth and antibiotic tolerance by modulating protein aggregation and translational arrest.

bioRxiv · Feb 10, 2026 · PreprintMicrobiology

Pneumo-Typer: integrated genomic surveillance tool for capsule genotype, serotype and sequence type in Streptococcus pneumoniae informs vaccine strategies

Xiangyang Li, Haitao Zhang, Yaoyao Zhu, Zilin Yang, Xiangyu Wang, Guohui Zhang, Xuan Zhao, Yinyan Huang, B Q Li, Zhongrui Ma

Pneumo-Typer identifies capsule genotype variations in Streptococcus pneumoniae genomes, revealing CapT diversity and informing vaccine strategies.

bioRxiv · Feb 13, 2025 · PreprintBioinformatics