Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson disease expressing human full-length and C-terminally truncated 1-120 alpha-synuclein.
Francesca Longhena, Z Zheng, Gaia Faustini, Michał Węgrzynowicz, E Carlson, Nicolas Casadei, O Riess, Arianna Bellucci, Maria Grazia Spillantini
This study shows that co-expressing human full-length and C-terminally truncated alpha-synuclein in mice increases alpha-synuclein aggregation and dopaminergic neuron loss, supporting the MI2BACo mouse model as a tool for Parkinson's disease research.
bioRxiv · Apr 13, 2025 · PreprintNeuroscience