Author

Michał Węgrzynowicz

University of CambridgeORCID 0000-0002-5082-9576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Maria Grazia SpillantiniiD· 3 shared Aleksandra Owczarek· 2 shared Aleksandra SkweresiD· 2 shared Jeffrey W. DalleyiD· 2 shared Laura Calò· 2 shared Martyna PodgajnaiD· 2 shared Oleg V. AnichtchikiD· 2 shared Omar Basheer· 2 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Maria Grazia SpillantiniORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

LOSS OF ARGINASE 2 DISRUPTS STRIATUM-SPECIFIC POLYAMINE HOMEOSTASIS

Martyna Podgajna, Omar Basheer, Mariusz Radkiewicz, Katarzyna Skowrońska, Aleksandra Skweres, Aleksandra Owczarek, Agata Dalka, Wojciech Hilgier, Magdalena Zielińska, Emilia Samborowska, Michał Węgrzynowicz

This study investigates the metabolic role of Arg2 in striatal neurons, finding that its loss disrupts polyamine homeostasis and alters metabolite levels in Arg2 knockout mice.

FEBS Journal · Oct 31, 2025Peer-reviewedNeuroscience

Mitochondrial Calcium Uniporter protects hippocampal CA2 neurons from excitotoxic injury

Aleksandra Skweres, M Beresewicz, Omar Basheer, Martyna Nalepa, Aleksandra Owczarek, Maria Kawalec, Joanna Gruszczynska‐Biegala, Barbara Zabłocka, Michał Węgrzynowicz

The paper investigates the role of the Mitochondrial Calcium Uniporter (MCU) in protecting hippocampal CA2 neurons from excitotoxic injury, finding that MCU expression correlates with resistance to NMDA-induced damage.

bioRxiv · May 27, 2025 · PreprintNeuroscience

Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson disease expressing human full-length and C-terminally truncated 1-120 alpha-synuclein.

Francesca Longhena, Z Zheng, Gaia Faustini, Michał Węgrzynowicz, E Carlson, Nicolas Casadei, O Riess, Arianna Bellucci, Maria Grazia Spillantini

This study shows that co-expressing human full-length and C-terminally truncated alpha-synuclein in mice increases alpha-synuclein aggregation and dopaminergic neuron loss, supporting the MI2BACo mouse model as a tool for Parkinson's disease research.

bioRxiv · Apr 13, 2025 · PreprintNeuroscience

CSPα reduces aggregates and rescues striatal dopamine release in αsynuclein transgenic mice

Laura Calò, Eric Hidari, Michał Węgrzynowicz, Jeffrey W. Dalley, Bernard Laurent Schneider, Martyna Podgajna, Oleg V. Anichtchik, Emma Carlson, David Klenerman, Maria Grazia Spillantini

This study shows that CSP reduces synuclein aggregates and restores dopamine release in a Parkinson's disease mouse model.

Brain · Mar 10, 2021Peer-reviewedNeuroscience

Depopulation of α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson disease model

Michał Węgrzynowicz, Dana Bar-On, Laura Calò, Oleg V. Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W. Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantini

This study develops a new Parkinson's disease mouse model showing that reducing α-synuclein aggregates rescues dopamine neuron dysfunction and death.

Acta Neuropathologica · May 31, 2019Peer-reviewedNeuroscience