Olaf Rieß

This study identifies genomic features, particularly copy-number alterations, that predict metastatic progression in melanoma and defines a six-gene signature associated with relapse.

MethylBench benchmarks DNA methylation profiling methods across sequencing platforms, finding consistent DMC hotspots and highlighting platform-specific strengths and limitations.

This paper presents a Nanopore-only workflow for diploid T2T genome assembly and haplotype-resolved 3D chromatin maps, achieving high accuracy without hybrid polishing.

This study shows that co-expressing human full-length and C-terminally truncated alpha-synuclein in mice increases alpha-synuclein aggregation and dopaminergic neuron loss, supporting the MI2BACo mouse model as a tool for Parkinson's disease research.

The paper presents a high-quality genome assembly for the ant Lasius platythorax using long-read sequencing and Hi-C, providing insights into the genomic basis of trait differentiation in ant species.

This study shows that overexpression of human alpha-synuclein in rats leads to gut microbiome dysbiosis, altered metabolites, and aging-related changes that can be modulated by antibiotics.

The paper identifies and compares the abundance of ATXN3 splice variants in blood and cerebellum of SCA3/MJD patients and controls, finding tissue-specific expression patterns of full-length ataxin-3 isoforms.

This study analyzes genome and transcriptome data from discordant monozygotic twins with Mayer-Rokitansky-Kuster-Hauser syndrome to identify genetic and transcriptional differences.

This study uses Raman microspectroscopy to detect α-Synuclein aggregates in a rat model of Parkinson's disease, showing promise for early diagnosis.

This paper introduces Swarm Learning, a decentralized machine learning approach for disease classification using transcriptomic data, demonstrating its effectiveness in developing classifiers for COVID-19, tuberculosis, and leukemias while preserving privacy.

This study profiles endometrial tissue from MRKH syndrome patients using RNA-seq to identify altered transcription patterns and candidate genes involved in the syndrome.

This study identifies nine genetic loci associated with age at onset in Machado-Joseph disease, suggesting roles for DNA repair and synaptic pathways in disease progression.

This paper describes a novel Ataxin-3 knock-in mouse model that replicates key neuropathological, behavioral, and transcriptional features of human SCA3 disease.

This study shows that enriched environments reduce inflammation markers in Parkinson's disease mice by altering gut bacteria.