Author

Z. Hayouka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:bacteria (other)· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:mouse· 1

Frequent Co-Authors

B. Maron· 2 shared E. Malach· 2 shared A. Yehuda· 1 shared B. Antunes· 1 shared C. Witzany· 1 shared C. Zanchi· 1 shared D. Kadosh· 1 shared D. Lereclus· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. Maron

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is severely constrained by random peptide mixtures

B. Antunes, C. Zanchi, P. R. Johnston, B. Maron, C. Witzany, R. R. Regoes, Z. Hayouka, J. Rolff

This study shows that random antimicrobial peptide mixtures reduce resistance evolution in Pseudomonas aeruginosa compared to single peptides, preventing cross-resistance and maintaining drug sensitivity.

bioRxiv · Feb 22, 2024 · PreprintMicrobiology

Nature-Inspired Peptide of MtDef4 C-terminus Tail Enables Protein Delivery in Mammalian Cells

L. Adriana-Lifshits, Y. Breuer, M. Sova, S. Gupta, D. Kadosh, E. Weinberg, Z. Hayouka, D. z. Bar, M. Gal

This study evaluates a 16-residue peptide from Medicago truncatula defensin for its ability to penetrate mammalian cells and deliver cargo, showing efficient uptake and minimal cytotoxicity.

bioRxiv · Sep 14, 2023Cell Biology

Reactivating the complement system using peptidic bacterial labeling tag

Y. Belo, E. Malach, Z. Hayouka

This paper develops a method to reactivate the complement system against complement-resistant bacteria by conjugating a peptide binder to a complement protein, achieving 90% eradication of E. coli.

bioRxiv · Jul 9, 2023 · PreprintMicrobiology

Quorum sensing peptidic inhibitor rescue host immune system eradication: a novel QS infectivity mechanism

A. Yehuda, E. Malach, L. Slamti, S. Shuan Kuo, J. Z. Lau, M. Whan Oh, J. Adeoye, N. Shlezinger, G. Lau, D. Lereclus, Z. Hayouka

The paper designs a peptide-based QS inhibitor that reduces Bc virulence by blocking immune system eradication in mouse models.

bioRxiv · Oct 28, 2022Microbiology

The C-terminal tail of CSNAP attenuates the CSN complex

M. G. Füzesi-Levi, G. Ben-Nissan, D. Listov, Z. Hayouka, S. Fleishman, M. Sharon

The paper shows that a C-terminal peptide from CSNAP can displace CSNAP from the CSN complex, reducing CSN activity and CRL function, suggesting a new therapeutic approach.

bioRxiv · Jul 18, 2022Biochemistry

Combination treatment can hinder the evolution of resistance to antimicrobial peptides

B. Maron, J. Friedman, Z. Hayouka

This study shows that combination antimicrobial peptide treatments can delay and reduce the evolution of resistance in S. aureus compared to single AMPs.

bioRxiv · Mar 13, 2022 · PreprintEvolutionary Biology