Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
T. Orre, Z. Karatas, B. Kastberger, C. Cabriel, R. T. Boettcher, S. Leveque-Fort, J.-B. Sibarita, R. Faessler, B. Wehrle-Haller, O. Rossier, G. Giannone
The paper shows kindlin uses membrane diffusion and localization to the integrin nano-layer to activate integrins in focal adhesions, distinct from talin's mechanism.
bioRxiv · Aug 6, 2020Cell Biology