B. Wehrle-Haller

The human-restricted oncoprotein POU5F1B enhances cell invasiveness through plasma membrane remodeling

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

Akt Drives TGF-beta-induced Over-secretion of DKK1 and Impairment of Cystic Fibrosis Airway Epithelium Polarity

This study shows that Akt signaling drives TGF-beta-induced over-secretion of DKK1 and impairs apicobasal polarity in CF airway epithelium, with therapeutic targeting of these pathways restoring polarization.

New tools to study the interaction between integrins and latent TGFbeta1

The paper develops new tools to study how integrin Vβ6 interacts with latent TGFβ1, revealing unique mechanical rearrangements and binding differences with LAP1 and LAP3.

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

The paper shows kindlin uses membrane diffusion and localization to the integrin nano-layer to activate integrins in focal adhesions, distinct from talin's mechanism.

Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force

This study shows that mechanical force increases the ligand promiscuity of αVβ3 integrin by enabling binding to fibronectin through conformational changes.