Author

Z. Melegh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 1

Frequent Co-Authors

D. Catchpoole· 4 shared K. Malik· 4 shared M. Szemes· 4 shared J. Bellamy· 3 shared M. Kollareddy· 3 shared A. Greenhough· 2 shared J. H. Park· 2 shared A. Dallosso· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

D. Catchpoole

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4 papers

Recent·Most cited

Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities

M. Szemes, Z. Melegh, J. Bellamy, J. H. Park, B. Chen, A. Greenhough, D. Catchpoole, K. Malik

bioRxiv · Jan 11, 2021Cancer Biology

A Wnt-BMP4 signalling axis induces MSX and NOTCH proteins and promotes growth suppression and differentiation in neuroblastoma

M. Szemes, Z. Melegh, J. Bellamy, M. Kollareddy, D. Catchpoole, K. Malik

This study shows that Wnt-BMP4 signaling induces MSX and NOTCH proteins, leading to growth suppression and differentiation in neuroblastoma.

bioRxiv · Feb 7, 2020Cancer Biology

Increased efficacy of histone methyltransferase G9a inhibitors against MYCN-amplified Neuroblastoma

J. Bellamy, K. Malik, M. Szemes, Z. Melegh, A. Dallosso, M. Kollareddy, D. Catchpoole

This study shows G9a inhibitors are more effective against MYCN-amplified neuroblastoma, with G9a depletion triggering apoptosis specifically in these cells.

bioRxiv · Nov 22, 2019Cancer Biology

Wnt signalling drives context-dependent differentiation or proliferation in neuroblastoma

M. Szemes, A. Greenhough, Z. Melegh, S. Malik, A. Yuksel, D. Catchpoole, K. Gallacher, M. Kollareddy, J. H. Park, K. Malik

This study identifies Wnt target genes in neuroblastoma and shows Wnt signalling can drive differentiation in some cell lines and proliferation in others.

bioRxiv · Jan 12, 2018Cancer Biology