Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation
E. D. Queathem, Z. Moazzami, D. B. Stagg, A. B. Nelson, K. Fulghum, A. Hayir, A. Seay, J. R. Gillingham, D. A. d`Avignon, X. Han, H.-B. Ruan, P. A. Crawford, P. Puchalska
The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.
bioRxiv · Jul 9, 2024Biochemistry