Author

P. A. Crawford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

P. Puchalska· 5 shared A. B. Nelson· 2 shared C. C. Hughey· 2 shared A. D. Patterson· 1 shared A. Kupai· 1 shared B. M. Dickson· 1 shared B. M. Oswald· 1 shared C. M. Krawczyk· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersPhysiology

P. Puchalska

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

M. Alexander, V. Upadhyay, R. Rock, L. Ramirez, K. Trepka, P. Puchalska, D. Orellana, Q. Y. Ang, C. Whitty, J. A. Turnbaugh, Y. Tian, D. Dumlao, R. R. Nayak, A. D. Patterson, J. C. Newman, , P. J. Turnbaugh

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

bioRxiv · Nov 2, 2023Microbiology

Gender-based heterogeneity of FAHFAs in trained runners

A. B. Nelson, L. S. Chow, D. R. Dengel, M. Pan, C. C. Hughey, X. Han, P. Puchalska, P. A. Crawford

The paper compares FAHFA levels in lean and overweight runners, finding gender-based differences and associations with body composition and metabolic factors.

bioRxiv · Jun 7, 2023Physiology

Metformin impairs trophoblast metabolism and differentiation in dose dependent manner

S. K. Nashif, R. M. Mahr, S. Jena, S. Jo, A. B. Nelson, D. Sadowski, P. A. Crawford, P. Puchalska, E. U. Alejandro, M. D. Gearhart, S. A. Wernimont

This study shows that high-dose metformin impairs trophoblast metabolism and differentiation, while therapeutic doses do not.

bioRxiv · Feb 14, 2023 · PreprintCell Biology

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

F. I. Rome, G. L. Shobert, W. C. Voigt, D. B. Stagg, P. Puchalska, S. C. Burgess, P. A. Crawford, C. C. Hughey

This study shows that loss of hepatic PEPCK1 impairs acute exercise glucose regulation but improves liver lipid reduction and muscle mitochondrial adaptations with exercise training in mice.

bioRxiv · Sep 22, 2022Physiology

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

K. M. Luda, S. M. Kitchen-Goosen, E. H. Ma, M. J. Watson, L. R. Duimstra, B. M. Oswald, J. Longo, Z. Fu, Z. Madaj, A. Kupai, B. M. Dickson, I. Kaymak, K. Lau, S. Compton, L. M. DeCamp, , R. G. Jones

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

bioRxiv · Aug 26, 2022 · PreprintImmunology