Gadolinium-based nanoparticles AGuIX and their combination with ionizing radiation trigger AMPK-dependent proinflammatory reprogramming of tumor-associated macrophages
Z. Muradova, D. Tannous, A. Mostefa-Kara, T. T. Cao-Pham, C. Lamy, S. Broutin, A. Paci, S. Dufort, T. Doussineau, F. Lux, O. Tillement, G. Le Duc, A. Allouch, j.-l. PERFETTINI
This study shows that AGuIX nanoparticles and their combination with ionizing radiation induce proinflammatory reprogramming of tumor-associated macrophages via AMPK-dependent mitochondrial fragmentation.
bioRxiv · Jan 12, 2024 · PreprintImmunology