Structural studies reveal that endosomal cations promote formation of infectious CVA9 A particles, facilitating RNA and VP4 release.
A. Domanska, Z. Plavec, V. Ruokolainen, B. Löflund, V. Marjomäki, S. J. Butcher
This paper shows that endosomal cations and albumin promote CVA9 capsid expansion and genome release by destabilizing the virion structure and exposing repulsive inner surfaces.
bioRxiv · Sep 2, 2022 · PreprintMicrobiology