S. J. Butcher

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

The structure of immature tick-borne encephalitis virus

This study determines the structure of immature TBEV using cryoEM, revealing the organization of surface glycoproteins and the role of prM cleavage in viral maturation.

Simultaneous Membrane and RNA Binding by Tick-Borne Encephalitis Virus Capsid Protein

This study investigates how tick-borne encephalitis virus capsid protein binds membranes and recruits RNA, showing electrostatic interactions and membrane insertion.

Structural studies reveal that endosomal cations promote formation of infectious CVA9 A particles, facilitating RNA and VP4 release.

This paper shows that endosomal cations and albumin promote CVA9 capsid expansion and genome release by destabilizing the virion structure and exposing repulsive inner surfaces.

Proteome-wide cross-linking mass spectrometry to identify specific virus capsid-host interactions between tick-borne encephalitis virus and neuroblastoma cells

This paper identifies 59 high confidence virus-host protein interactions between tick-borne encephalitis virus and neuroblastoma cells using chemical cross-linking and mass spectrometry.

Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses

This paper identifies a conserved virion-stabilizing network in the VP1-VP3 interprotomer pocket of enteroviruses, revealing how new capsid binders stabilize the virus structure.

2.8 A resolution cryo-EM structure of human parechovirus 3 in complex with Fab from a neutralizing antibody

The paper presents a 2.8 Å cryo-EM structure of HPeV3 complexed with a neutralizing antibody, revealing epitope details and RNA interactions critical for viral assembly and neutralization.