Transthyretin has conformation-selective proteolytic activity against α-synuclein
Z. Sarkany, T. Giao, M. A. Liz, A. Planas, S. Macedo-Ribeiro, I. Cardoso, G. Arsequell, P. M. Martins
This study shows that transthyretin (TTR) selectively proteolyzes specific conformations of alpha-synuclein (aSyn), preventing its aggregation, with implications for neurodegenerative diseases.
bioRxiv · Aug 10, 2023 · PreprintBiochemistry