Cell BiologybioRxiv
Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs
A. Lorzadeh, C. Hammond, D. Knapp…·M. Hirst
The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.