M. Hirst

Human lymphoid-neutrophil/monocyte restriction co-ordinately activates increased proliferation despite parallel heterogeneity in transcriptional changes

The paper identifies shared proliferation acceleration and heterogeneous transcriptional changes during B-lymphoid and neutrophil/monocyte lineage restriction from CD34+ cord blood cells.

Genome-wide CRISPR screen identifies KEAP1 perturbation as a vulnerability of ARID1A-deficient cells

The paper identifies KEAP1 as a genetic dependency in ARID1A-deficient clear cell ovarian carcinoma cells through a genome-wide CRISPR screen, showing KEAP1 perturbation leads to growth inhibition.

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

Global prediction of candidate R-loop binding and R-loop regulatory proteins

The paper develops a random forest classifier to predict R-loop binding proteins using proteomic features and amino acid composition, and validates new R-loop modulating proteins through CRISPR screening.

YB-1 IS REQUIRED FOR THE GENESIS AND METASTATIC CAPACITY OF HUMAN BREAST CANCER

This study shows YB-1 is essential for human breast cancer growth and metastasis, as its knockdown inhibits tumor formation and lung colonization in mice.

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment

This study examines methylation changes in cell-free DNA of mCRPC patients during androgen-targeting therapy, finding that persistent methylation changes correlate with longer time to clinical progression.

The pathognomonic FOXL2 C134W mutation alters DNA binding specificity

This study investigates the molecular effects of the FOXL2 C134W mutation in AGCT by analyzing DNA binding and transcriptome changes in engineered cell lines.

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.