Structural dynamics and immunogenicity of the recombinant and outer membrane vesicle-embedded Meningococcal antigen NadA
V. Calvaresi, L. Dello Iacono, S. Borghi, E. Luzzi, A. Biolchi, B. Benucci, I. Ferlenghi, I. Peschiera, F. Giusti, L. E. Fontana, Z.-Y. Kan, Z. Spinello, M. Merola, I. Delany, K. D. Rand, N. Norais
This study compares the structural dynamics and immunogenicity of recombinant NadA and OMV-embedded NadA, showing that the native form elicits stronger immune responses.
bioRxiv · Jan 30, 2024Biophysics