Molecular basis of UHRF1 allosteric activation for synergistic histone modification binding by PI5P
P. Mandal, Z. Yerkesh, V. Kharchenko, L. Zandarashvili, D. Bensaddek, L. Jaremko, B. E. Black, W. Fischle
This study identifies how PI5P allosterically activates UHRF1 to synergistically bind H3unmodified and H3K9me3 histone marks through conformational changes.
bioRxiv · Aug 4, 2021 · PreprintBiochemistry