Author

D. Bensaddek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Assay:proteomics· 5 Organism:human· 3 Organism:C. elegans· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

A. I. Lamond· 5 shared A. Brenes· 2 shared E. A. Miska· 2 shared K. M. Suen· 2 shared A. Akay· 1 shared A. Sapetschnig· 1 shared A. Tanpure· 1 shared B. E. Black· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBiochemistry

A. I. Lamond

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Author profile →

7 papers

Recent·Most cited

Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

H. Jiang, J. Druker, J. W. Wilson, D. Bensaddek, J. R. Swedlow, S. Rocha, A. I. Lamond

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

bioRxiv · Jul 28, 2023 · PreprintBiochemistry

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

I. C. Navarro, K. M. Suen, D. Bensaddek, A. Tanpure, A. I. Lamond, S. Balasubramanian, E. A. Miska

The paper identifies reader proteins for 5-methylcytosine and its derivatives in C. elegans RNA using modified RNA baits and mass spectrometry.

bioRxiv · Jan 24, 2022Biochemistry

Molecular basis of UHRF1 allosteric activation for synergistic histone modification binding by PI5P

P. Mandal, Z. Yerkesh, V. Kharchenko, L. Zandarashvili, D. Bensaddek, L. Jaremko, B. E. Black, W. Fischle

This study identifies how PI5P allosterically activates UHRF1 to synergistically bind H3unmodified and H3K9me3 histone marks through conformational changes.

bioRxiv · Aug 4, 2021 · PreprintBiochemistry

Arabidopsis Proteome and the Mass Spectral Assay Library

H. Zhang, P. Liu, T. Guo, H. Zhao, D. Bensaddek, R. Aebersold, L. Xiong

The paper generates a comprehensive Arabidopsis proteome atlas and library, then uses DIA-MS to study abscisic acid effects, identifying differentially expressed proteins.

bioRxiv · Jun 16, 2019Plant Biology

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

K. M. Suen, F. Braukmann, R. Butler, D. Bensaddek, A. Akay, C.-C. Lin, N. Doshi, A. Sapetschnig, A. I. Lamond, J. E. Ladbury, E. A. Miska

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.

bioRxiv · Mar 16, 2019 · PreprintCell Biology

Optimising multi-batch TMT analysis to mitigate inflation of missing values, false positives and diminished inter batch accuracy

A. Brenes, J. L. Hukelmann, D. Bensaddek, A. I. Lamond

The paper evaluates the impact of integrating multiple TMT batches in proteomic analysis and proposes solutions to reduce missing values, false positives, and inter-batch accuracy issues.

bioRxiv · Dec 16, 2018 · PreprintBiochemistry

The iPSC proteomic compendium

A. Brenes, D. Bensaddek, J. Hukelmann, V. Afzal, A. I. Lamond

The paper presents a proteomic analysis of 217 HipSci iPSC lines, identifying >16,000 protein groups and their roles in iPSC biology.

bioRxiv · Nov 14, 2018 · PreprintBiochemistry