A Metabolic Sum Rule Dictates Bacterial Response to Short-Chain Fatty Acid Stress
B. R. Taylor, V. Patsalo, H. Okano, Y. Shen, Z. Zhange, J. R. Williamson, J. D. Rabinowitz, T. Hwa
The paper identifies a metabolic sum rule in bacteria showing that exogenous metabolite accumulation depletes endogenous metabolites, causing growth reduction, and demonstrates how cells mitigate this by acidifying their cytoplasm.
bioRxiv · Aug 31, 2022 · PreprintMicrobiology