Author

J. R. Williamson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:cryo-EM· 3 Organism:E. coli· 3 Approach:statistical model· 3 Organism:bacteria (other)· 2 Research Focus:clustering· 2 Approach:deep learning· 2

Frequent Co-Authors

D. Lyumkis· 4 shared K. Sheng· 4 shared J. N. Rabuck-Gibbons· 3 shared X. Dong· 3 shared V. Patsalo· 2 shared A. Courbois· 1 shared A. M. Popova· 1 shared A. X.-Z. Zhou· 1 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersBiophysics

D. Lyumkis

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Assembly of the Bacterial Ribosome with Circularly Permuted rRNA

J. R. Williamson, X. Dong, K. Sheng, L. F. R. Gebert, S. Aiyer, I. MacRae, D. Lyumkis

This study investigates bacterial ribosome assembly using circularly permuted rRNAs, revealing conserved assembly routes and domain association order.

bioRxiv · Apr 10, 2024Biophysics

Proteome partitioning constraints on long-term laboratory evolution

M. Mori, V. Patsalo, J. R. Williamson, M. Scott

The paper investigates proteome remodeling in bacterial lineages over 40,000 generations and identifies sector-specific adaptations in metabolic enzyme expression.

bioRxiv · Sep 8, 2023Microbiology

Early HIV-1 Gag Assembly on Lipid Membrane with vRNA

A. X.-Z. Zhou, J. A. Hammond, K. Sheng, D. P. Millar, J. R. Williamson

The paper uses mass photometry to study HIV-1 Gag assembly with vRNA on lipid membranes, showing trimerization and gradual hexamer formation.

bioRxiv · Jan 27, 2023 · PreprintBiophysics

Near-Physiological in vitro Assembly of 50S Ribosomes Involves Parallel Pathways

X. Dong, L. K. Doerfel, K. Sheng, J. N. Rabuck-Gibbons, A. M. Popova, D. Lyumkis, J. R. Williamson

The paper reports the assembly of 50S ribosome intermediates using in vitro reconstitution and cryo-EM, revealing parallel assembly pathways and cooperative blocks.

bioRxiv · Nov 9, 2022Biochemistry

Unsupervised Voxel-based Segmentation reveals a Landscape of Bacterial Ribosome Large Subunit Early Assembly

K. Sheng, N. Li, J. N. Rabuck-Gibbons, X. Dong, D. Lyumkis, J. R. Williamson

The paper uses cryo-EM and a new segmentation method to reveal the early assembly pathway of bacterial ribosome large subunit, identifying cooperative blocks and a unified maturation landscape.

bioRxiv · Nov 9, 2022 · PreprintBiochemistry

A Metabolic Sum Rule Dictates Bacterial Response to Short-Chain Fatty Acid Stress

B. R. Taylor, V. Patsalo, H. Okano, Y. Shen, Z. Zhange, J. R. Williamson, J. D. Rabinowitz, T. Hwa

The paper identifies a metabolic sum rule in bacteria showing that exogenous metabolite accumulation depletes endogenous metabolites, causing growth reduction, and demonstrates how cells mitigate this by acidifying their cytoplasm.

bioRxiv · Aug 31, 2022 · PreprintMicrobiology

Pre-B cell receptor acts as a selectivity switch for Galectin-1 at the pre-B cell surface

P. Touarin, B. Serrano, A. Courbois, O. Bornet, Q. Chen, L. G. Scott, S. J. C. Mancini, J. R. Williamson, C. Sebban-Kreuzer, L. Elantak

The paper shows the pre-B cell receptor changes Galectin-1's binding specificity from exo- to endo-type, promoting pre-B cell survival.

bioRxiv · Feb 8, 2022Biochemistry

Quantitative Mining of Compositional Heterogeneity in Cryo-EM Datasets of Ribosome Assembly Intermediates

J. N. Rabuck-Gibbons, D. Lyumkis, J. R. Williamson

The paper develops a workflow to quantitatively analyze structural heterogeneity in cryo-EM datasets, applied to E. coli ribosome assembly intermediates to identify new branch points and interactions.

bioRxiv · Jun 23, 2021Biophysics