J. D. Rabinowitz

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

Adaptations to water stress and pastoralism in the Turkana of northwest Kenya

The paper identifies genetic regions associated with adaptation to water stress and pastoralism in the Turkana people using genome sequencing.

Systematic identification and characterization of novel genes in the regulation and biogenesis of photosynthetic machinery

The paper identifies 70 novel genes involved in photosynthesis regulation and biogenesis using genetics in Chlamydomonas reinhardtii and characterizes their functions through mutant proteomics.

Tissue-Specific and Interorgan Metabolic Reprogramming Maintains Tolerance to Sepsis

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

A Metabolic Sum Rule Dictates Bacterial Response to Short-Chain Fatty Acid Stress

The paper identifies a metabolic sum rule in bacteria showing that exogenous metabolite accumulation depletes endogenous metabolites, causing growth reduction, and demonstrates how cells mitigate this by acidifying their cytoplasm.

NAD precursors cycle between host tissues and the gut microbiome

The paper shows NAD precursors cycle between host tissues and the gut microbiome to maintain NAD homeostasis.

Slow TCA flux implies low ATP production in tumors

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

Methionine synthase supports tumor tetrahydrofolate pools

This study shows methionine synthase (MTR) is crucial for cells to avoid folate trapping and assimilate 5-methyl-THF into other folate species, supporting one-carbon metabolism and tumor growth.

A dual-mechanism antibiotic targets Gram-negative bacteria and avoids drug resistance

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect

The paper shows that nutrient-growth dysregulation in yeast leads to the evolution of a metabolic defect involving organosulfur release, which confers a fitness advantage under specific conditions.

E. coli translation strategies differ across nutrient conditions

This study shows E. coli uses different translation strategies under carbon, nitrogen, and phosphate limitations to maintain protein production rates while adapting to nutrient availability.