ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor Neurons
Zachary Osking, Jacob I. Ayers, Ryan P. Hildebrandt, Kristen Skruber, Hilda H. Brown, Daniel H. Ryu, Amanda R. Eukovich, Todd Eliot Golde, David Borchelt, Tracy‐Ann Read, Eric A. Vitriol
The paper shows that mutant SOD1 increases axonal outgrowth, dendritic branching, and actin-based structures in adult motor neurons from ALS mouse models, suggesting a potential therapeutic target.
iScience · Dec 27, 2018Peer-reviewedNeuroscience